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When p53 is inactivated, the accumulation of DNA damage leads to sustained senescence induction through p16 expression 29

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GHK-Cu exists as a 1:1 copper(II):peptide complex in which the Cu(II) ion is coordinated by the glycine terminal amino group, the amide nitrogen between glycine and histidine, the histidine imidazole nitrogen, and the lysine side chain amino group in a square planar arrangement

10.1371/journal.pone.0159085 173 WuL.HanZ.WangS.WangX.SunA.ZuX.et al