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In Europe, only Moldova, Kosovo, and, most recently, the United Kingdom mandate fortification of food with folic acid 693

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High doses of acetaminophen can deplete the body's glutathione stores, which are necessary to neutralize the toxic metabolites of acetaminophen

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Notably, activation of such pro-inflammatory mechanisms can directly cause excess generation of oxidation products that precede the onset of atherosclerosis and endothelial dysfunction, which are major risk factors for the development of cardiovascular diseases (Rose et al., 2010