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GSH depletion is driven through esterase catalyzed release of quinone methide intermediates carboxylic ester of B2C
Through these reactions as well as its interactions with a number of proteins, glutathione is one of the major regulators of cancer cell development, progression, response to therapy and its environment leading to a number of avenues for therapeutic targeting (Figure 1)
This is not an overnight wrinkle treatment
Therefore, it is necessary to develop a better toolkit and standardize methods of isolation and analysis of specific subset of exosomes from in vivo tumor tissue
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