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The results showed significant discontinuation rates: 26.2% at three months, 30.8% at six months, and 36.5% at 12 months

Linagliptin is the exception, with 10,000 patients, exposed for up to 2 years) of the sitagliptin and vildagliptin clinical trials have been published, showing no increased risk for urinary tract or respiratory infections or headache (and indeed, no increased risk of any other adverse effect) with the DPP-4 inhibitors compared to placebo or comparator [95,96]

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