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Lurcher Mutation and Neuropathology Morphological Change in the Lurcher Cerebellum and Inferior Olive Compared to non-mutants (called wild-type mice, WT), the cerebellum is reduced to approximately 71% in Lurcher mice, where 95% of the PCs die between postnatal days 8 and 25 [67, 68] (Fig
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When SIRT3 removes acetyl groups from isocitrate dehydrogenase 2 (IDH2), more NADPH gets made in mitochondria
By July 2019, the study had enrolled approximately 30% of its intended participants, with an estimated completion of enrollment by the first quarter of 2020 and the study concluding by the first quarter of 2021
Gao, Q., Kou, T., Zhuang, B., Ren, Y., Dong, X., & Wang, Q
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