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Significant hormonal side effects are uncommon, especially compared to older growth hormonereleasing peptides

Furthermore, there may be bioavailability differences and metabolism differences as well (inactive, active, toxic metabolites)

In an era where bioactive compounds are a click away, patients will increasingly run real-world experiments ahead of our evidence base

The most extensively studied mechanism involves upregulation of vascular endothelial growth factor (VEGF), which promotes angiogenesis, the formation of new blood vessels at injury sites, providing the vascular supply necessary for accelerated tissue repair

ETHICS STATEMENT Responsibility for editorial decisions and peer review process for this article was delegated to nonauthor Editors or nonauthor Associate Editors

10.5897/ajar2018.13755 J