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& Sahni, J

Given the regenerative potential of hMSC, understanding how GLP-1-RA affect these cells is crucial for determining further implications of these drugs on tissue homeostasis and metabolic health

While losing weight is an effect of the drug itself, its also due to diet changes caused by GLP-1s (3)

The peptide's resistance to dipeptidyl peptidase-IV (DPP-IV) proteolysis is achieved through substitution of -methyl-Phe at position 2, which blocks the cleavage of the Tyr1Ala2 bond that normally inactivates native incretins within minutes of secretion

Understanding where GLP-1 is produced helps explain how the body maintains metabolic balance and why GLP-1-based medications have become important therapeutic options

The data indicate that the hydrogen bonds formed in this binding mode are not very reliable, and the fluctuations in the RMSD during the latter part of the simulation confirm the instability of CME_c