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Patients should follow the instructions provided by their clinician and the current patient information leaflet
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These include: Nausea (the most frequently reported adverse effect) Vomiting Diarrhoea Constipation Decreased appetite (which, while contributing to weight loss, can occasionally be excessive) These effects were generally mild to moderate in severity and occurred most frequently during the dose-escalation phase
For most people, an FDA-approved brand or oral option is now the safer path
Retatrutide benefits stem from its unique status as a "triple agonist." While popular drugs like Ozempic mimic one hormone (GLP-1) and Mounjaro mimics two (GLP-1 and GIP), Retatrutide introduces a third player: Glucagon
The clinical significance of this added increase in serum creatinine relative to placebo is not known
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