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Patients on any oral antihyperglycemic agent in monotherapy (N=212) or on a PPAR agent in combination therapy (N=106) or not on an antihyperglycemic agent (off therapy for at least 8 weeks, N=34) were switched to monotherapy with pioglitazone (at a dose of 30-45 mg per day), and completed a run-in period of approximately 12 weeks in duration

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Of the 19 studies, nine studies reported a significant increase in serum GLP-1 levels

Omega-3 Fatty Acids (150 mg): These essential fats may help with heart health and manage blood pressure and triglycerides