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Zhang, W Zhang

The fall in electron potential energy through this electron transport chain (ETC) is used to pump protons out the mitochondrial matrix to the intermembrane space (IMS)

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Each component addresses a different bottleneck in the regeneration process, and removing all three bottlenecks simultaneously produces results none could achieve independently

This can lead to a folate deficiency

The lack of consensus on the therapeutic dose and duration outlines the paucity of clinical evidence supporting the benefit of vitamin E supplementation in BBS, mainly because of its extremely low incidence