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Importantly, this pathway is enzymatically tractable, as the enzymes that control CoQ 10 reduction are druggable oxidoreductases, making the CoQ 10 axis a promising pharmacological entry point for ferroptosis-based cancer therapy

The total synthesis of melanotan II was concluded by coupling N -acetylnorleucine to the cyclic hexapeptide using a combination of DCC and HONb (Scheme 1)

Increased mtDNA copy number promotes cancer progression by enhancing mitochondrial oxidative phosphorylation in microsatellite-stable colorectal cancer

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