Growth hormone peptides (CJC-1295, ipamorelin, sermorelin) are particularly relevant for this population because endogenous GH production declines approximately 14% per decade after age 30
Most studied potential mechanisms include neuroplasticity effect, oxidative stress and neurotransmitter regulation
The pivotal trial randomized 412 HIV-infected patients with abdominal fat accumulation to 2 mg of subcutaneous tesamorelin daily or placebo for 26 weeks, in a double-blind, placebo-controlled design
Identifying predictive biomarkersincluding genetic variants (e.g., Hp genotype), markers of mitochondrial function, inflammatory cytokine profiles, and integrated metabolic signatureswill enable stratification of patients according to likely benefit
Simon analyze commercial insurance claims for approximately 537,000 patients who initiated GLP-1 treatment between 2017 and 2022
In December 2025, Melissa Mendoza, director of CBERs Office of Compliance shared, [t]he reorganization, among its many benefits, has led to streamlined compliance reviews
