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What we know The biology may be interesting, but the consumer claim needs direct human evidence

Given that beneficial roles of GLP1 analogues for the prevention of CVD and kidney disease have been well established 80,102 , these drugs could be an ideal option for the treatment of patients with diabetes mellitus at such risk 103

doi: 10.1186/s40880-018-0301-4 46 JonesSFInfanteJR

Is the suggested superiority of tirzepatide in terms of weight reduction a result of a better GLP-1 receptor agonism, or is it primarily the addition of the GIP receptor agonism that impacts body weight regulation or is it perhaps a combination of the two

Phentermine was designed as a short-term intervention

Most nausea is mild to moderate and occurs during dose escalation