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Nusinersen, as a modified ASO, has shown effectiveness in enhancing motor function across different forms of SMA, according to evidence from open-label and randomized controlled studies

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However, in studying how cerebellar Purkinje cells change their responsiveness to a particular stimulus during learning of conditioned responses, it has been shown that these cells can learn the temporal relationship between two paired stimuli

Annu Rev Cancer Biol 8:3558 Lister G (1993) Metabolic responses to hypoxia