What they found (summary): Amylin is a critical partner of insulin in metabolism, the loss of amylin in T2DM is as significant as the loss of insulin The AMY1 receptor in the area postrema is the primary target for the appetite effect Amyloid aggregation is the main problem with native amylin, proline substitutions (the Pramlintide strategy) are essential The half-life of native amylin is only 13 minutes, that is why lipidated analogs like Cagrilintide are necessary Perspective: amylin + GLP-1 combinations are the natural evolution of metabolic pharmacotherapy Why it matters: This is the reference article for amylin pharmacology
A new gastric juice peptide, BPC, heals both acute and chronic gastrointestinal lesions. Journal of Physiology (Paris), 95(1-6), 7992
CJC-1295 stimulates growth hormone-releasing hormone (GHRH) signaling, while ipamorelin activates ghrelin receptors
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What is the difference between subcutaneous and intramuscular injections for BPC-157
If a dose is missed, inject as soon as remembered if within three days of the scheduled dose