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Rash or irritation at the injection site: Irritation from the medication or preservatives can cause injection site redness, pain, or swelling

Protocol (adapted from refs 2 and 3) Carry out all operations (except step 5) at 4C 1

doi:10.1016/j.lfs.2013.03.008

Research indicates DSIP may help normalize disrupted circadian rhythms in subjects with shift work disorder, jet lag, or age-related sleep disturbances characterized by reduced slow-wave sleep

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In this assay, the 30 min incubation duration was chosen to be optimal because of the inherently cytotoxic nature of CuCl 2 and Cu(OAc) 2 towards HaCaT keratinocytes, as they were observed to cause substantial cell death at a duration longer than 30 mins