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"They're clearly on patients' minds, and that's worth paying attention to," says Sehgal

These have been shown in models of muscle injury, tendon degeneration, and experimental colitis

Note: Adults under 130 lbs may benefit from using a 29G " or 25G 5/8" needle to achieve intramuscular delivery, based on injection site and medical advice

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[1] These are meaningful cosmetic endpoints, and they map logically onto the mechanism: more collagen and glycosaminoglycan synthesis, better-organized remodeling, and reduced oxidative and inflammatory burden should, in principle, translate into firmer, smoother, more resilient skin