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[21] Individuals of 677TT are predisposed to mild hyperhomocysteinemia (high blood homocysteine levels), because they have less active MTHFR available to produce 5-methyltetrahydrofolate (which is used to decrease homocysteine)

CREB and ATF1 can be phosphorylated at the critical Ser-133 and Ser-63 residues, respectively, by cAMP/PKA

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