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The doctors want to be honest with their patients

Any significant weight loss at this point is usually water weight or reduced food intake from nausea, not fat loss

Of the 1822 participants on a GLP-1 RA, 72% (1309 individuals) were still on therapy for at least 3 years

This extra receptor interaction enhances glucagon production, leading to the breakdown of stored fats and glycogen, thereby increasing basal metabolism for more consistent fat loss

Developed as part of a new class of multi-receptor agonists, Retatrutide is designed to target several hormonal pathways involved in appetite regulation, glucose metabolism, and energy expenditure

In type 2 diabetes populations across 38 phase III/IV trials, the rate was lower at 19.3% versus 6.5% on placebo