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Sublingual (under-the-tongue) GLP-1 agonists, such as semaglutide, represent a novel approach, promising similar benefits to injectable versions without the need for needles

This route however appears to be largely ignored and probably will continue to be ignored, since the strategy so far has been to simply create agonists which are structurally designed to be resistant to DPP-4 (In fact, most modifications to extend the half-life of GLP1R/GIPR/GR agonists so far, do so by making the drugs resistant to DPP-4 )

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The primary challenge for postbiotics lies in pharmacokinetics and delivery

From the perspective of R&D expansion, the era of GLP-1 drugs will see multiple players emerging, rather than being dominated by one or two companies