Ataxiatelangiectasia (AT) is a rare genome instability and neurocutaneous syndrome caused by biallelic mutations in the ataxiatelangiectasia mutated (ATM) gene, exhibiting an incidence of ~1:40,0001:300,000 live births in different communities worldwide and a median survival rate of ~25 years (Collyer and Rajan 2024)
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Specific dietary approaches can substantially improve GI tolerability: Reduce meal size and frequency
NFB-dependent inflammatory mediators produced in hepatocytes act to reduce insulin sensitivity and to promote liver injury
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Most titration schedules escalate weekly or every few weeks, meaning 0.6 mg is often a brief intermediate stepusually one to three weeks