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Individuals taking multiple antihypertensive agents particularly alpha-blockers, vasodilators, diuretics, SGLT2 inhibitors, tricyclic antidepressants, antipsychotics, nitrates, PDE5 inhibitors, or centrally acting antihypertensivesare at heightened risk, as the blood pressure-lowering effects of these medications may be potentiated by weight loss and volume changes associated with tirzepatide therapy

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