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Regular monitoring of hydration and kidney function is recommended

Furthermore, several additional alterations affecting children with IMDs like oxidative stress, inflammatory status, mineral loss and epigenetic effects, have been widely reported in space crew, and can be managed by appropriate nutritional countermeasures

Wu D, Govindasamy L, Lian W, Gu Y, Kukar T, Agbandje-McKenna M, McKenna R

Diabetes Ther (2019) 10(5):187992

It also appears to modulate the gastrointestinal side effects of GLP-1 activation, which may explain why tirzepatide is better tolerated despite being more potent