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There is a consensus that GPX and GCL are the two enzymes in the glutathione pathway that are upregulated by estradiol

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ROS homeostasis in cell survival and death The homeostasis of ROS within cells has a profound impact on cell fate, encompassing self-renewal, proliferation, differentiation, metabolic processes, and epigenetic landscape, all of which are affected by the oxygen environment and ultimately determine the process of cell death [212]