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In March 2025, a major new study was published in the journal Nature Medicine

Users who need flexibility in their dosing schedule might also explore how taking GLP-1 injections a day early affects the weekly cycle

For years, researchers avoided glucagon activation because glucagon raises blood sugar, which seemed counterproductive for a metabolic medication

10.1007/s00439-005-0123-8 39 FemminellaG

But change is in the air this year as demand for GLP-1 weight-loss drugs, like Ozempic, Wegovy, Mounjaro and Zepbound, is surging, particularly among older Americans, and studies are showing that climbing obesity rates may be slowing

The best recommendation is to have a washout period between taking GLP-1 agonists and getting pregnant