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Here are some early warning signs that you may have a mild to moderate deficiency: 5 Lack of energy Joint and muscle aches and pains Foggy brain Low immunity Poor sleep These are the symptoms of a severe insufficiency: 6 Anemia (low levels of iron) Metabolic acidosis (build-up of too much acid in the body) Frequent infections Seizures, Alzheimers disease, Parkinsons disease Loss of coordination (Ataxia) Liver disease Heart attack and stroke 7 If you feel like you have a deficiency, I recommend increasing supplemental glutathione levels using the methods I outline below