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Important Note on the Evidence Base Important note on the evidence base: The Dihexa research literature is entirely preclinical rodent behavioral models, in vitro hippocampal neuron culture, and mechanistic work characterizing HGF/c-Met-dependent signaling

Oral): Oral tablets are generally safe and are FDA approved for treating conditions like liver disease

Ishido, A

SAdenosylhomocysteine inhibits NF Bmediated gene expression in hepatocytes and confers sensitivity to TNF cytotoxicity

When an overdose of paracetamol is ingested, liver detoxification systems may become saturated and the large amount of NABQI produced exhausts the limited stores of glutathione

While providing health literacy education to teach distinguishment of APAP and NSAIDs is important, some have thought it possibly more beneficial to mitigate the chance of inappropriate APAP over-ingestion by reducing the pack size of APAP preparations sold, which they believe may reduce the incidence and severity of APAP hepatotoxicity