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FIGURE 4 3 Therapeutic effects of bioactive metabolites in DKD Natural active substances such as polyphenolic metabolites, peptides, polysaccharides, flavonoids, and so on, originate from nature, and have the advantages of high safety, multi-targeted action, abundant resources, and sustainable utilization, which show a great potential for the treatment of DKD (Mitra et al., 2025

doi: 10.1186/s10194-019-0993-0 2

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The epidermal growth factor receptor family: biology driving targeted therapeutics