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Glp1r expression is undetectable by quantitative PCR in peritoneal or adipose tissue macrophages (37), although Lyz2 -Credriven deletion of Glp1r ( Glp1r Lyz2/ ) abolishes expression in bone marrowderived macrophages (38)

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In conclusion, the current study suggests that loss of hepatic GLP-1R in NAFLD patients is responsible for low responsiveness to GLP-1 therapy

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