In fact, 4HT interacts with ERs with a similar binding affinity as the endogenous estrogen, 17 -estradiol (E 2 ), whereas the prodrug shows a 100-fold lower affinity than 4HT ( Tamoxifen and other ER ligands are defined as selective estrogen receptor modulators (SERMs), in that they induce tissue-selective ER agonist or antagonist effects depending on the interaction with tissue-selective transcriptional coregulators that are recruited by each ligand-specific receptor conformation ( -positive breast cancers as an antagonist of estrogen signaling in mammary epithelial cells, yet it provides secondary ER -agonist effects in bone, preventing osteoporosis ( Importantly, compelling evidence points to off-target responses to the prodrug, tamoxifen, which are mediated by ER-unrelated, low-affinity effectors described in various cell lineages and physio-pathological conditions
Heart surgery
BMJ 27(350):h25 Schafer AL, Kazakia GJ, Vittinghoff E et al (2018) Effects of gastric bypass surgery on bone mass and microarchitecture occur early and particularly impact postmenopausal women: bone mass and microarchitecture after gastric bypass surgery
An Albumin Random Urine Test with Creatinine may add information for people with diabetes or other kidney-risk factors
A model of redox kinetics implicates the thiol proteome in cellular hydrogen peroxide responses
Drinking plenty of water is so important when taking creatine supplements." - Zane B
