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GSH depletion led to defects in actin-based motility and cell-to-cell spread

Substantial human trial data for full-length TB-4 (corneal-healing Phase 2/3 as RGN-259, plus cardiac and wound-repair programs), with clean Phase 1 safety. Cosmetic dosing is extrapolated from these programs

Elevated fractional exhaled nitric oxide (FeNO), a byproduct of arginine conversion, has been linked to disease progression and lung function decline in IPF patients [83], indicating its potential as a non-invasive biomarker

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It is one of the most metabolically active tissues in the body, which means it produces a lot of free radicals