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Rare cases of intestinal obstruction have been reported with some agents

Rinaldi G, Pranzini E, Van Elsen J et al (2021) In vivo evidence for serine biosynthesis-defined sensitivity of lung metastasis, but not of primary breast tumors, to mTORC1 Inhibition

Nagashima T, Shigematsu N, Maruki R, Urano Y, Tanaka H, Shimaya A, et al Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: Improvement of fasting glycemia in diabetic db/db mice Mol Pharmacol

Does the loading phase cause more bloating