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The moment a patient hits a dose that causes troublesome nausea or loss of appetite beyond whats manageable, Nooms clinician-designed protocol holds at that dose longer, or even dials back to the prior dose until symptoms subside

doi: 10.1093/ajcn/nqac075

But experts agree if you're seeing results at the starter dose, you don't have to change

Nobody knew where it would lead, and several of the participants are unfortunately now deceased

Critical sterile steps include: Sterile filtration using 0.22-micron filters Nitrogen blanketing (if required) Controlled mixing under aseptic conditions The sterile solution is transferred to the filling line without exposure to external contamination