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Together, they maintain hepatic redox homeostasis against continuous oxidative challenges from metabolism, xenobiotics, and inflammation (Figure 4) [98]

We chose to express the bifunctional glutathione synthetase gshF gene from Streptococcus thermophilus, which encodes for glutamate cysteine ligase (GCL) and glutathione synthetase (GS) to synthesise GSH, as well as cytosolic isoforms of glutathione peroxidase (GPX5) and glutathione reductase (GSHR1) from Chlamydomonas reinhardtii

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If further research supports these effects on substance overuse, these drugs could revolutionize the treatment of addiction, experts say