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The GLP-1 receptors in the mesolimbic brain region are thought to help modulate reward behaviour

In rabbits, doses of 0.072 mg/kg/day, which is approximately 10 times the recommended human subcutaneous starting dosage of 0.2 units/kg/day on a mg/kg basis, were administered during organogenesis

Moreover, several large-scale clinical trials 6,7,8,9,10 such as LEADER, SUSTAIN-6, and REWIND have demonstrated that GLP-1RAs can reduce the incidence of MACEs in patients with T2D and established cardiovascular disease or high cardiovascular risk

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127 , 962S965S (1997)

High-Dose Vitamin C: High-dose IV Vitamin C (25g+) acts as an oxidant, as opposed to lower doses where it is an antioxidant