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Dual inhibition of the lactate transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

Research has also showed promising results in Alzheimer's disease animal models, where NAD+ supplementation improved cognition and helped nerves regenerate

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De Vadder F, Kovatcheva-Datchary P, Goncalves D, Vinera J, Zitoun C, Duchampt A, et al

The mechanism works synergistically with other GHK-Cu effects

Invest Ophthalmol Vis Sci 54(12):73957401 Das S et al (2018) Identification of a novel gene in ROD9 island of Salmonella enteritidis involved in the alteration of virulence-associated genes expression