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In vitro studies using normal human epidermal keratinocytes revealed that treatment with glutathione amino acid precursors significantly increased both GSH and glutathione disulfide levels, leading to an improved GSH/glutathione disulfide ratio, which is a key indicator of cellular redox balance

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Nevertheless, to date, nearly all reported STING antagonists necessitate frequent highdose intraperitoneal administration due to their rapid systemic clearance (for instance, H151 demonstrates a circulation halflife of less than 2 h after injection)