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The progressive decline in mitochondrial function, characterized by impaired ATP synthesis, excessive ROS production, and structural abnormalities, triggers a vicious cycle involving energy crises, oxidative stress, and inflammatory responses, ultimately accelerating cardiomyocyte death [129, 130]

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doi: 10.1016/s0196-9781(03)00040-8

Glycine, though technically classified as a non-essential amino acid, becomes conditionally essential when the body is under high oxidative demand, as the endogenous synthesis cannot keep up with the rapid consumption

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