Research has characterised PT-141 as a direct MT-II derivative produced by C-terminal amide hydrolysis , documenting preserved cyclic heptapeptide structure, maintained MC3R/MC4R pro-sexual activity, and reduced MC1R-mediated pigmentation activity relative to MT-II
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10.1080/14786419.2014.965165 220 ZhimeiL.NingL.YapingJ.JiameiY.JieZ.MiaoS.et al (2019)