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Easier to measure small doses precisely

Some studies have shown greater average weight loss with tirzepatide compared with semaglutide, but the best choice depends on the patients medical history, treatment goals, side-effect tolerance, metabolic risk, and physician evaluation

Semaglutides effects last for several weeks after a single injection

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Nevertheless, a retrospective analysis of T2DM treatment in UK showed that the mean time to add a second oral agent in patients with A1c above 7.0, 7.5 and 8.0%, was 2.9, 1.9 and 1.6 years, respectively

Research presented at Heart Rhythm 2026 followed more than 13,000 patients and found GLP-1 medication use tied to a lower risk of atrial fibrillation, regardless of how much weight patients lost, including patients who gained weight