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McClean, P

GI Adverse Effects of Glucagon-Like Peptide-1 Receptor Agonists These agents are commonly used therapies for managing diabetes and obesity, but gastrointestinal adverse effects such as nausea, vomiting, diarrhea, and constipation frequently limit therapy

Notably, studies in mice demonstrate that GLP-1R agonists specifically localize to and require arginine vasopressin neurons in the PVN to exert their hypophagic and weight-reducing effects, a process that is amplified by GIPR co-activation [81]

And your body does not care that you are losing weight intentionally with semaglutide or tirzepatide

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As researchers learn more about the biological processes involved in appetite and metabolism, weight management shifts from a matter of willpower to a complex but medically treatable condition