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Factors influencing APAP-related hepatotoxicity The most essential determining factor in both the development and severity of APAP hepatotoxicity is the drugs ingested dose, but some argue that the length of time from APAP ingestion to N -acetylcysteine (NAC) therapy (time to NAC) is equally if not more important.15,1720 Many other factors are confluent in the development and severity of liver injury after APAP over-ingestion (Table 1)

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