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The headline numbers Semaglutide produced a 20 percent reduction in major adverse cardiovascular events (MACE), the composite of cardiovascular death, nonfatal heart attack, and nonfatal stroke
Interestingly, W-24 (106), a non-peptide GLP-1RA, has been reported to inhibit inflammatory pain by stimulating the spinal cord GLP-1R for the release of analgesic -endorphin
The trial data doesnt capture much of this
The reason injectable GLP-1 drugs like semaglutide and liraglutide work is that they are chemically modified versions of the hormone
Suspected side effects should be reported through the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk or via the Yellow Card app)
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