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Start conservatively, track progress, adjust based on results

10.1080/0886022x.2024.2356021 22 ChenL.YeZ.WangD.LiuJ.WangQ.WangC.et al (2022)

Those with type 1 diabetes or insulin-dependent type 2 diabetes must consult their endocrinologist before fasting on GLP-1s, as fasting reduces calorie intake and can increase hypoglycemia risk without medication adjustment

The Kraus 2014 Nature paper established that NNMT is highly expressed in adipose tissue (especially in obesity) and that NNMT knockdown in adipose protects against diet-induced obesity in mice

Its critical to see your physician to screen for these common conditions and treat them if found. Additionally, Maselli recommends asking your healthcare professional if other medications you take list weight gain as a possible side effect

While GLP-1's role in insulin secretion and appetite regulation has been well characterized, GIP has historically been less studied