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According to FDA prescribing information for semaglutide and liraglutide, hypersensitivity reactions are rare but possible

Kim EJ, Kim YK, Kim JE, et al

Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease

Patients on semaglutide , for example, often notice continued appetite regulation even several days after missing a single weekly dose

Patients planning pregnancy GLP-1 medications must be discontinued before conception

Although the researchers replicate a clinical trial finding of a reduction in heart attacks and strokes among patients with existing cardiovascular disease and chronic kidney disease and a reduction in moderate alcohol consumption risk, they find no statistically significant decline in broader emergency department visits or in any major diagnostic category