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In an embodiment, the C 16 -C 22 fatty acid is selected from the group consisting of stearic acid, arachadic acid and eicosanedioic acid

However, there is not much evidence that they are altered in vivo by DPP4i and there have been no adverse reactions or safety issues caused by off-target effects of DPP4i on other endogenous substrates [46,47]

The gamma-glutamyl cycle should be considered not as a mechanism for amino acid transport but rather a generator of extracellular signals, gamma-glutamyl amino acids, that are converted intracellularly to 5-oxoproline, which activates uptake and/or metabolism of amino acids (1, 74, 75)

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Eligibility is primarily based on BMI, though this is not the only consideration