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[11] Clinical studies such as the SUSTAIN programme (semaglutide) and AWARD trials (dulaglutide) demonstrate that GLP-1 receptor agonists can reduce HbA1c by approximately 0.81.5% on average, with some patients achieving greater reductions depending on baseline values and adherence

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This is all based on the best health guidance obtained from UK pharmacists and health care professionals

Several case reports of unplanned pregnancies during semaglutide use have not identified clear patterns of congenital anomalies, but this sample size is too small to establish definitive safety, which is why regulatory agencies recommend avoidance