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Compared with other CVOTs involving GLP-1RA, participants in the AMPLITUDE-O trial had the longest duration of diabetes (15 years), lowest mean eGFR (72 ml/min/1.73 m 2 ) with a higher percentage (32%) of people with renal disease (eGFR 2560 mL/min), highest glycosilated hemoglobin (8.9%), and highest percentage of insulin use (62%) or sodiumglucose transporter-2 inhibitors (SGLT-2i) (15%) at baseline, thus identifying a more fragile population

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The weight loss trajectory for compounded semaglutide mirrors clinical trial data: meaningful loss by week 34, cumulative reduction of 515% by week 12, and sustained benefits at months 46

Ozempic (semaglutide): Though not officially FDA-approved for weight loss, it leads to 10-12% body weight reduction in many patients

Some medicines can cause unwanted or dangerous effects when used with sildenafil