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Semaglutide (marketed as 'Ozempic' and 'Wegovy') and the dual-agonist Tirzepatide ('Mounjaro' and 'Zepbound') are some of today's most talked-about medications, given their unprecedented clinical efficacies across both weight loss and T2D management

Conversely, population studies have found no association between increased risk of diabetic retinopathy and GLP-1 RA use [104, 105], with a low odds ratio observed for exenatide (OR 0.16), liraglutide (OR 0.18), albiglutide (OR 0.09), and dulaglutide (OR 0.11) [106]

Ozempic and Wegovy are FDA-approved finished drugs that are trademarks of their respective owner

Prior authorization for GLP-1 medications is typically required regardless of plan type

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This review explores the mechanisms, clinical development, and therapeutic potential of these novel agents, excluding already approved drugs like liraglutide, semaglutide, and tirzepatide