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its overexpression significantly reduces GPX4 protein levels, exacerbating lipid peroxidation and ferroptosis, and targeted inhibition of METTL3 can affect the m6A modification level of GPX4, ultimately affecting cellular sensitivity to ferroptosis (Meng et al., 2024)

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The anaesthetics prilocaine and lidocaine along with the herbicide propanil also undergo hydrolysis in humans 11,12,13 and exposure to their amine metabolites has been shown to induce methaemoglobinemia in vitro and in patients 3,13,14

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A significant reduction was observed in proteinuria (19.1 mg/g, p = 0.000